Here at Diamond Lane Doodles we test for a number of canine DNA related diseases, we also have BVA hip and elbow scores done on all of our dogs
The Australian Labradoodle Breed average hip score is 12 (a score given between 0 and 106) the lower the better, anything under 20 is acceptable so we rate our dogs with scores as follows
0-5 perfect, 6-10 excellent, 11-15 very good, 16-20 good
​
We test DNA for CNM, CY, DM, EIC, HNPK, HUU, NEwS, HUU, PKD, PRA-prcd, SD2, vWD1
​
Labrador Centronuclear Myopathy (CNM or CM)
Description:
Centronuclear Myopathy (CNM), previously known as HMLR, or Hereditary Myopathy, is an autosomal recessive mutation that causes insufficient muscle function in the Labrador Retriever breed. This is due to the centralisation of the nuclei in muscle fibers, caused by a missense insertion in the PTPLA gene.
​
Canine Cystinuria (CY)
Description:
Canine Cystinuria is an autosomal recessive disorder that affects a dog's ability to filter cystine out of urine. Normally, tubules in the kidney are responsible for re-absorption of cystine, filtering it out of the urine. In dogs with Canine Cystinuria, the tubules are unable to transport the cystine, allowing it to accumulate in the urine. Cystine is generally insoluble in the acidic conditions of canine urine, allowing it to crystallize and form caliculi, also known as stones.
​
​
Degenerative Myelopathy (DM)
Description:
Degenerative Myelopathy (DM) is a progressive neurological disorder that affects the spinal cord of dogs. Dogs that have inherited two defective copies will experience a breakdown of the cells responsible for sending and receiving signals from the brain, resulting in neurological symptoms.
The disease often begins with an unsteady gait, and the dog may wobble when they attempt to walk. As the disease progresses, the dog's hind legs will weaken and eventually the dog will be unable to walk at all. Degenerative Myelopathy moves up the body, so if the disease is allowed to progress, the dog will eventually be unable to hold his bladder and will lose normal function in its front legs. Fortunately, there is no direct pain associated with Degenerative Myelopathy.
​
​
Exercise-Induced Collapse (EIC)
Description:
Exercise-Induced Collapse (EIC) is an autosomal recessive genetic disorder causing affected dogs to suffer from a loss of muscle control following periods of extreme exercise. Typically, an affected dog begins to show symptoms between 5 months and 3 years of age, usually around the age that more intensive training begins.
EIC episodes generally occur after 5-25 minutes of extreme exercise. Not all types of exercise can induce an attack; generally the dog must be actively running and excited for an extended period of time. The attacks often begin with rocking, followed by the hind limbs becoming weak and giving out. The severity of these attacks ranges between different dogs; some will continue to attempt to retrieve, dragging their hind legs along, and other will be totally unable to move, acting disoriented. These attacks usually only last about 5-25 minutes, however, in some extreme cases, dogs have died immediately following an EIC attack
​
​
Hereditary Nasal Parakeratosis (HNPK)
Description:
Hereditary nasal parakeratosis (HNPK) is an inherited autosomal recessive disorder in Labrador Retrievers. A mutation T>G in the SUV39H2 gene causes the nose to dry out leading to chronic irritation and inflammation of the noses skin.
​
​
Hereditary Hyperuricosuria (HUU)
Description:
Dogs with this genetic mutation metabolize waste product s as uric acid in their urine. The uric acid forms into hard stones in the bladder, causing pain and inflammation as the stone moves through the urinary tract.
​
​
Neonatal Encephalopathy with Seizures (NEwS)
Description:
Neonatal encephalopathy with seizures (NEWS) is an autosomal recessive disease of standard poodle puppies. Affected puppies are small and weak at birth. Many die in their first week of life. Those surviving past 1 week develop ataxia, a whole-body tremor and by 4 to 6 weeks of age, severe generalized clonic-tonic seizures. None have survived to 7 weeks of age. Cerebella from affected puppies were reduced in size.
​
​
Progressive retinal Atrophy, progressive Rod-cone degeneration or PRA-prcd
Description:
Progressive retinal Atrophy, progressive Rod-cone degeneration, or PRA-prcd, is a disorder in which the cells in the retina of a dog degenerate and die. PRA is the dog equivalent of retinitis pigmentosa in humans. Most affected dogs will not show signs of vision loss until 3-5 years of age. Complete blindness can occur in older dogs. Progressive Rod-Cone Degeneration is a form of PRA known to affect over 40 different breeds.
The retina is a membrane located in the back of the eye that contains two types of cells known as photoreceptors. These cells take light coming into the eyes and relay it back to the brain as electrical impulses. These impulses are interpreted by the brain as vision. In dogs suffering from PRA-prcd, the photoreceptors begin to degenerate, causing an inability to interpret changes in light resulting in loss of vision. Rod cells, which are normally function in low-light, begin to degenerate first, leading to night-blindness. The cone cells, which normally function in bright-light or daytime conditions, will deteriorate next. This often leads to complete blindness over time.
​
​
Skeletal Dysplasia 2: dwarfism in the Labrador Retriever
Description:
Canine Skeletal Dysplasia 2 (SD2) is a mild form of disproportionate dwarfism found in Labrador Retrievers. It is generally characterized by one or more body parts being smaller in comparison to the overall size of the animal. Animals with SD2 develop legs that are shorter than unaffected legs, despite a normal body size. In most cases, the front legs are more severely affected than the hind legs. This causes an awkward stance and gait.
​
​
von Willebrand's Disease Type I
Description:
Von Willebrand disease (vWD) is an inherited bleeding disorder that inhibits the normal blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience excessive bruising, prolonged nosebleeds, and excessive bleeding following any form of trauma, including surgery, or dental work.
The primary function of von Willebrand factor (vWF) a blood glycoprotein, is to bind itself to other proteins. The deficiency or failure of vWF function inhibits the blood coagulation process and causes bleeding which is most apparent in tissues having high blood flow or narrow vessels.
​
To find out more about bva hip and elbow scores please click here https://chs.bva.co.uk/help/understanding-the-results.html
​
​